Abstract
SUMMARY The composition of the lipids of normal human bone marrow has been determined. Marrows were obtained postrmortem from the femurs of 12 subjects ranging in age from 1 to 78 years. The total extractable lipid, which varied from 28% to 84% of the tissue wet weight, waa composed primarily of neutral lipid. It contained less than 3% of phospholipid and no detectable carbohydrate. The neutral lipid consisted of 96% to 98% triglyceride and minor amounts of free cholesterol and free fatty acids. Fractions representative of hydrocarbons, cholesterol esters, diglycerides, and monoglycerides were not detected. The fatty acids of the triglyceride fraction were analyzed by gas-liquid chromatography. The predominant fatty acids were palmitic and oleic, which accounted for an average of 26% and 46%, respectively, of the total. Myristic, palmitoleic, stearic, and linoleic acids were also present but in smaller amounts. The composition of the lipids of bone marrow has been studied in the rabbit (1, 2), and the total amount of lipid has been determined for a number of species (3), but information as to the nature of these lipids in man is lacking. This investigation has been carried out with the express purpose of ascertaining the normal composition of the lipids of human bone marrow, a tissue of particular interest to us because of its relative importance in xanthomatous diseases.
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