Abstract
1. 1. In rats, the addition of 0.5% cholesterol to diets containing various levels of linoleic acid resulted in accumulation of liver cholesterol ester; the magnitude of the accumulation was not related in an apparent manner to the amount of linoleic acid. There was little or no increase in plasma cholesterol except in animals on a fat-free diet. 2. 2. The polyunsaturated fatty acid (PUFA) content of the plasma esters decreased markedly, and cholesterol arachidonate largely disappeared. 3. 3. The influx of cholesterol in the liver was accompanied by increases in the amounts of dienoic and trienoic ester, but tetraenoic and pentaenoic esters did not change. 4. 4. Feeding a diet containing 2 % cholesterol for 28 days resulted in decreased incorporation of acetate into the “octabromide” fraction of liver lipides, suggesting that the formation of arachidonic acid from linoleic acid was impaired.
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