Abstract
The human gene for dopamine β-hydroxylase (DβH) has been mapped to chromosome 9q34. Using polymerase chain reaction amplification of exon 11 of the DβH gene followed by digestion of the reaction products with FnuDII ( BstUI), we detected a low-frequency restriction fragment length polymorphism (RFLP). The CEPH panel of family DNAs was genotyped for this RFLP, enabling us to determine the linkage relationships between DβH and four other loci previously mapped to human chromosome 9q. We obtained two-point recombination frequencies (θ) between DβH and arginosuccinate synthetase (θ = 0, LOD = 7.37), the ABO blood group locus (θ = 0, LOD = 4.5), CRI-P111 (θ = 0, LOD = 2.1), and D9S31 (θ = .06, LOD = 2.81).
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