Abstract
The protective action of epoxy lining on rubber stoppers of natural, neoprene, and butyl rubber was evaluated against unlined stoppers of the same composition for sorption of preservative from vial solutions and extractives leached from closures into the solution. For the preservatives tested—namely, p -chloro- β -phenylethyl alcohol and its nonchlorinated analog, phenylethyl alcohol—no protective action against sorption was exhibited by the lined closures. The solutions used in the extractives study were water, 10 per cent ethanol, 50 per cent polyethylene glycol 300, 50 per cent N , N -dimethylacetamide, and 2 per cent benzyl alcohol. The lining on the closures was found to afford protection against leaching. For both the sorption and extractives studies, the butyl rubber closures exhibited optimal stability.
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