Abstract
The ability fo lindane to change the metabolism of inositol phospholipids was investigated using rat renal proximal tubular cell cultures labelled with [ 3H]inositol. Lindane addition to the culture medium caused labelling of inositol trisphosphate, inositol bisphosphate and inositol tetrakishosphate to decrease and that of the inositol monophosphate pool to increase. A depletion of radioactivity in phosphatidylinositols was also observed after lindane addition. Most strikingly, the addition of lindane considerably increased the levels of glycerophospho-inositol in a dose-dependent manner. The effect of lindane follows a different pattern from that of bradykinin, and it is suggested to act by stimulating phospholipase A activity(ies). IP-inositol monophosphate; IP 2-inositol bisphosphate; IP 3-inositoll trisphosphate, IP 4-inositol tetrakisphosphate; GPI-glycerophosphoinositol; PI-phosphatidylinositol; PIP-phosphatidylinositol monophosphate; PIP 2-phosphatidylinositol bisphosphate; TCA-trichloroacetic acid; DMEM-Dulbecco's Modified Eagle's Medium; DMEMab-DMEM supplemented with penicillin (100 IU/ml), streptomycin (100 μg/ml) and fungizone (0.25 μg/ml); BSA- bovine serum albumin
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