Abstract
Purpose: Articular cartilage is known for having low regenerative abilities, turning osteoarthritic (OA) lesions irreversible. Lin28a, a Let-7 miRNAs inhibitor, is involved in several tissues repair such as bone. Lin28a is mediated by HMGA2, a chromatin remodeling factor inhibited by Let-7 miRNA. We have previously shown that Lin28a may induce stem cell reprograming through the activation of anabolic pathway. The aim of the study is to uncover the mechanism of action of Lin28a in cartilage repair.
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