Abstract
A novel cyclovirus, CyCV-VN, was recently identified in cerebrospinal fluid (CSF) from patients with central nervous system (CNS) infections in central and southern Vietnam. To explore the geographic distribution of this novel virus, more than 600 CSF specimens from patients with suspected CNS infections in northern Vietnam, Cambodia, Nepal and The Netherlands were screened for the presence of CyCV-VN but all were negative. Sequence comparison and phylogenetic analysis between CyCV-VN and another novel cyclovirus recently identified in CSF from Malawian patients indicated that these represent distinct cycloviral species, albeit phylogenetically closely related. The data suggest that CyCV-VN has a limited geographic distribution within southern and central Vietnam. Further research is needed to determine the global distribution and diversity of cycloviruses and importantly their possible association with human disease.
Highlights
A novel cyclovirus, CyCV-VN, was recently identified in cerebrospinal fluid (CSF) from patients with central nervous system (CNS) infections in central and southern Vietnam
To explore the geographic distribution of this novel virus, more than 600 CSF specimens from patients with suspected CNS infections in northern Vietnam, Cambodia, Nepal and The Netherlands were screened for the presence of CyCV-VN but all were negative
These data suggest that cycloviruses may have a wide geographic distribution, and that specific CyCV species might be associated with specific clinical phenotypes, it should be noted that associated pathology of cycloviruses has yet to be proven
Summary
A novel cyclovirus, CyCV-VN, was recently identified in cerebrospinal fluid (CSF) from patients with central nervous system (CNS) infections in central and southern Vietnam. The virus was subsequently detected in 4% of 642 CSF samples of patients with central nervous system (CNS) infections from 7 different provinces in southern and central Vietnam, but in none of 122 CSF samples from patients with noninfectious CNS conditions[6] Almost simultaneously, another novel CyCV (CyCV-VS5700009) was reported in CSF and serum from patients with paraplegia in Malawi[7], while other CyCVs have previously been reported in stool samples of patients with acute flaccid paralysis from Tunisia, Pakistan and Nigeria[3]. Another novel CyCV (CyCV-VS5700009) was reported in CSF and serum from patients with paraplegia in Malawi[7], while other CyCVs have previously been reported in stool samples of patients with acute flaccid paralysis from Tunisia, Pakistan and Nigeria[3] Together, these data suggest that cycloviruses may have a wide geographic distribution, and that specific CyCV species might be associated with specific clinical phenotypes, it should be noted that associated pathology of cycloviruses has yet to be proven
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