Abstract
Much attention has focused on cationic liposomes for delivery of antisense oligonucleotides. While these reagents demonstrate efficient delivery and potentiation of antisense oligonucleotides in vitro under serum-free conditions, then-use in vivo may be limited. This report highlights issues including serum-instability, biodistribution, and target-nonspecificity that may hinder their use for efficient nucleic acid delivery in vivo. Given the many advantages of liposomes for drug delivery, alternative liposome formulations of nucleic acid are discussed.
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