Abstract
This paper investigates the effects of different light regimes (constant light, LL; constant darkness, DD; standard light regime, LD; 12 h light/12 h darkness, natural light of northwest Russia, NL) on the dynamics of lifetime morbidity, spontaneous carcinogenesis, and the incidence of certain types of nontumorous pathologies that were identified during autopsy of male rats. As well, it was found that keeping the animals from the age of 25 days under conditions of LL and NL led to an increased frequency of infectious diseases, significantly more rapid development of spontaneous tumors, and expansion of the range and frequency of non-neoplastic diseases as compared with animals that were under standard light conditions (LD). Light deprivation (DD) contributed to a significant reduction of the incidence of neoplasm, non-neoplastic, and infectious diseases as compared with rats that were kept under standard lighting.
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