Abstract
Immunologists might have been relatively slow to recognize that lipids were not homogenously distributed within the plasma membrane but, once aware, they have been quick to appreciate its significance. Lipid rafts are unique membrane microenvironments that are enriched in sphingolipids and cholesterol, which have excited the interest of immunologists particularly because they sequester precious signaling molecules, including phosphatidylinositols, and lipid-modified proteins such as GPI-linked proteins, acylated src kinases, and the palmitoylated adaptor molecule LAT. In mature T cells, coaggregation of the T-cell receptor (TCR) with lipid rafts significantly enhances TCR signaling. Now, three recent reports indicate that immature T cells exploit lipid rafts to regulate cell fate.
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