Abstract
Abstract: Levetiracetam is a second-generation antiepileptic medication with a diverse array of mechanisms of action. Cutaneous adverse drug reactions (CADRs) associated with levetiracetam are infrequently reported in the literature. We present a case of a patient who developed a rash and desquamation due to levetiracetam treatment, which was completely resolved on cessation of the medication. We conduct a comprehensive review of the literature on CADRs associated with levetiracetam and propose a hypothesis regarding the underlying mechanism of this uncommon complication. We also highlight the importance of health-care providers being aware of the full range of potential adverse drug reactions associated with levetiracetam, including the occurrence of rash and desquamation. Prompt discontinuation of therapy is essential to reverse the associated effects. Further studies are needed to elucidate the pathophysiology of CADRs associated with levetiracetam and to develop strategies for prevention and management.
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