Abstract
AbstractHighlighting the potential of Iqbal multicomponent reaction (MCR), a streamlined two‐step MCR synthetic strategy is proposed for the rapid assembly of structurally complex tripeptidyl ketones, which are valuable building blocks for developing novel peptidomimetics. The approach utilizes consecutive Iqbal MCR and Ugi MCR under mild room temperature conditions, eliminating the need for laborious column chromatography purification. This work demonstrates Iqbal MCR's propensity to generate a diverse library of N‐(3‐oxopropyl) carboxamides containing carboxyl functionality, which can be readily elaborated further to tripeptidyl ketones through subsequent Ugi MCR.
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