Abstract
A group of healthy volunteers aged 60–93 years, was evaluated with respect to their NK activity. These people have been under careful medical observation for 3 years and were selected according to Senieur Protocol criteria. NK activity of each person was checked at least three times at regular 12-month intervals with the chromium release test and twice at the same interval of time with a single cell cytotoxicity assay. NK activity of 60–79-year-old females was in a similar range of values as that of young females (20–35 years) and was lower than that of the males of the corresponding age groups. The females aged 80–88 years revealed the highest NK activity. The chronically ill 80–88-year-old females, on the other hand, were characterized by a marked decrease of NK activity in relation to their age counterparts. NK activity of both the females and males significantly declined at the age of 89–93 years. The significance of NK activity for survival is discussed.
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