Abstract
.Significance: Researchers have made great progress in single-image super-resolution (SISR) using deep convolutional neural networks. However, in the field of leukocyte imaging, the performance of existing SISR methods is still limited as it fails to thoroughly explore the geometry and structural consistency of leukocytes. The inaccurate super-resolution (SR) results will hinder the pathological study of leukocytes, since the structure and cell lineage determine the types of leukocyte and will significantly affect the subsequent inspection.Aim: We propose a deep network that takes full use of the geometry prior and structural consistency of the leukocyte images. We establish and annotate a leukocyte dataset, which contains five main types of leukocytes (basophil, eosinophil, monocyte, lymphocyte, and neutrophil), for learning the structure and geometry information.Approach: Our model is composed of two modules: prior network and SR network. The prior network estimates the parsing map of the low-resolution (LR) image, and then the SR network takes both the estimated parsing map and LR image as input to predict the final high-resolution image.Result: Experiments show that the geometry prior and structural consistency in use obviously improves the SR performance of leukocyte images, enhancing the peak-signal-to-noise ratio (PSNR) by about 0.4 dB in our benchmark.Conclusion: As proved by our leukocyte SR benchmark, the proposed method significantly outperforms state-of-the-art SR methods. Our method not only improves the PSNR and structural similarity indices, but also accurately preserves the structural details of leukocytes. The proposed method is believed to have potential use in the wide-field cell prescreening by simply using a low-power objective.
Highlights
Image super-resolution (SR), which is a classic low-level task in the field of computer vision, aims at recovering high-resolution (HR) image from a given low-resolution (LR) image
This indicates that our prior network is able to predict parsing maps in very LR images
The estimated parsing map and LR images were both sent to the SR network, and HR images are reconstructed
Summary
Image super-resolution (SR), which is a classic low-level task in the field of computer vision, aims at recovering high-resolution (HR) image from a given low-resolution (LR) image. Convolutional neural network (CNN) has been introduced into the image SR problem. This powerful technology has brought new life to SR algorithms.. Image SR has become an important branch of computer vision tasks. It can be categorized into four types according to Yang’s work:[9] prediction models, edge-based methods, image statistical. Patch-based methods, especially those utilizing deep CNN models, achieve better performance than the other three methods. Bicubic interpolation loses most high-frequency information in LR images
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