Abstract
The transport of oxygen to tissues is crucial for tissue viability. Much research has been directed towards enhancing oxygen transport but there are situations in which oxygen, through the production of toxic oxygen metabolites (TOMs), can be detrimental. This is particularly so in the case of diseases affecting the blood vessels. Whilst the red blood cell is conventionally associated with oxygen carriage, the white blood cell is associated with the generation of TOMs or free radicals (FRs) which are generated as required to mediate the inflammatory and immunological responses. Increasing evidence now shows that another key event may also take place, namely the obstruction of the microcirculation by activated leucocytes and subsequent tissue injury by FRs released from the white blood cell(WBC).1
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