Abstract

To the Editor: The observation of Capodanno et al1 that increasing the frequency of administration of a low dose of aspirin has a more potent platelet inhibitory effect than increasing the daily dose of aspirin was of great interest to us because we observed a similar phenomenon several years ago in 206 patients with vascular diseases.2 It is noteworthy that although they did not observe a difference between the antiplatelet effects of once-daily (OD) and twice-daily (BID) administration of 162 mg aspirin, using the whole blood VerifyNow Aspirin test, they observed significantly lower platelet aggregation in …

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