Abstract
To the Editor: We read with interest the article by Simon et al1 regarding their recent study, from which we understand that the coadministration of proton pump inhibitors (PPIs) and clopidogrel after percutaneous coronary intervention is safe. The P450 enzyme system is responsible for the metabolism of clopidogrel.2,3 Hepatic cytochrome P450 (CYP) isoenzymes convert clopidogrel to its active metabolites through 2-step oxidation pathways.2, 4 The second pathway induces the formation of the active metabolite of clopidogrel.2, 3 The most important isoforms of human cytochrome P450 responsible of the transformation of …
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
