Abstract
We read with great interest the article by Grosser et al,1 “Drug Resistance and Pseudoresistance: An Unintended Consequence of Enteric Coating Aspirin,” which reports a trial conducted in healthy volunteers. The authors state, “Pharmacological resistance to aspirin is rare. Pseudoresistance, reflecting delayed and reduced drug absorption, complicates enteric coated but not immediate-release aspirin administration.” Finally, they conclude, “These observations question the value of seeking to diagnose aspirin resistance with single point-of-care diagnostic approaches.” Although we agree with the authors that plain aspirin “resistance” at peak (a few hours after immediate-release aspirin intake) is rare, we disagree with the conclusion stating that there is no …
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