Abstract
Viruses may not only affect our daily lives but also shape our genome evolution. A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG suppression in a biased manner. Genes involved in the defense against viral invaders are particularly CpG suppressed to avoid self-targeting and to promote an effective immune response.
Highlights
Viruses may affect our daily lives and shape our genome evolution
A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG suppression in a biased manner
Our innate immune system needs to initiate efficient defense mechanisms attacking the pathogen without markedly harming the host
Summary
A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG suppression in a biased manner. Genes involved in a1111111111 a1111111111 the defense against viral invaders are CpG suppressed to avoid self-targeting and to promote an effective immune response. These characteristics are exploited by antiviral host factors to preferentially target viral RNA, while sparing cellular transcripts.
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