Abstract
Less-invasive surfactant administration (LISA) is a technique whereby surfactant is given via a thin catheter inserted in the trachea. Although some current guidance has been to administer LISA in preterm infants with respiratory distress syndrome (RDS) without endotracheal intubation, the use of LISA differs across the world. The LISA technique allows the infant to remain on non-invasive ventilation support and avoids intubation and therefore mechanical ventilation. Practicalities around the procedure such as the use of premedication or the administration on delivery suite as prophylaxis are yet to be fully studied. Through recent meta-analyses, LISA has been shown to reduce the combined outcome of bronchopulmonary dysplasia (BPD) and mortality in preterm infants. This article summarises the evidence and discusses the practicalities of LISA in a clinical setting.
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