Abstract
Lesion-behavior mapping is an influential and popular approach to anatomically localize cognitive brain functions in the human brain. The present chapter provides a practical guideline for each step of the typical lesion-behavior mapping study pipeline, ranging from patient and imaging data, lesion delineation, spatial normalization, and statistical testing to the anatomical interpretation of results. An important aspect of this guideline at the statistical level will be to address the procedures related to univariate as well as multivariate voxelwise lesion analysis approaches.
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