Abstract
The recent developments in molecular biology made it possible to produce recombinant allergens. These allergens together with natural purified allergens are now available for specific IgE measurement either under an individual or a microarray format. Compared to natural extracts these standardized reagents represent an important breakthrough for the in vitro allergy diagnosis and they allow the precise characterisation of the sensitization profile of a given patient. Thus, we are now entering the molecular allergy era which will permit to conduct epidemiological studies, to improve the specificity of IgE determination (decrease of cross-reactivity and better understanding of polysensitization), to develop the component resolved diagnosis of allergy, to identify severity, persistence or recovery markers of allergy. These new technologies will be rapidly extended to skin tests, which will use molecular allergens and to a tailored immunotherapy defined according to the individual sensitization profile of the allergic patient.
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