Abstract
Autism as a neurodevelopmental disorder is characterized by persistent autistic features such as impaired social communication, restricted and repetitive behavior, and intellectual disabilities. As a disorder, autism has several ubiquitous co-morbidities, among which is sleep disorders, epilepsy, attention deficit, and hyperactivity. No effective treatment for the core symptoms of autism is available until now.
Highlights
Autism as one of the most common neurodevelopmental disorders is characterized by deficits in social communication, repetitive and restricted behaviors, with multiple sensory abnormalities
Studies of autism biomarkers can enhance our ability to predict abnormal development early in infancy and can proceed through early intervention that might be of great help because till effective medical treatments for the core symptoms of the disorder are still lacking
The variances of the biomarkers from the standard present the chance to create a panel of biomarkers that when selectively developed could result in an objective early diagnosis with direct correlation with the severity of autism for everyone [2,3,4,5,6,7,8]
Summary
Autism as one of the most common neurodevelopmental disorders is characterized by deficits in social communication, repetitive and restricted behaviors, with multiple sensory abnormalities. A biomarker is “a distinguishing variable that is accurately measured and assessed as a sign of normal biological manners, pathogenic status, or pharmacological responses to treatment strategy.”. They decrease our dependence on patients, caregivers, or clinician scores and are principally important for individuals who are unable to describe their physical or mental problems such as children with autism. There is great evidence about the alteration of amino acids, hormones, metabolites and other biomarkers in autistic individuals compared to age- and sex-matched controls These abnormalities can be observed in the gastrointestinal, immunologic, neurologic and toxicological systems of the body. The variances of the biomarkers from the standard present the chance to create a panel of biomarkers that when selectively developed could result in an objective early diagnosis with direct correlation with the severity of autism for everyone [2,3,4,5,6,7,8]
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