Abstract
To compare lens dimensions and refractive index distributions in type 1 diabetes and age-matched control groups. There were 17 participants with type 1 diabetes, consisting of two subgroups (7 young [23 ± 4 years] and 10 older [54 ± 4 years] participants), with 23 controls (13 young, 24 ± 4 years; 10 older, 55 ± 4 years). For each participant, one eye was tested with relaxed accommodation. A 3T clinical magnetic resonance imaging scanner was used to image the eye, employing a multiple spin echo (MSE) sequence to determine lens dimensions and refractive index profiles along the equatorial and axial directions. The diabetes group had significantly smaller lens equatorial diameters and larger lens axial thicknesses than the control group (diameter mean ± 95% confidence interval [CI]: diabetes group 8.65 ± 0.26 mm, control group 9.42 ± 0.18 mm; axial thickness: diabetes group 4.33 ± 0.30 mm, control group 3.80 ± 0.14 mm). These differences were also significant within each age group. The older group had significantly greater axial thickness than the young group (older group 4.35 ± 0.26 mm, young group 3.70 ± 0.25 mm). Center refractive indices of diabetes and control groups were not significantly different. There were some statistically significant differences between the refractive index fitting parameters of young and older groups, but not between diabetes and control groups of the same age. Smaller lens diameters occurred in the diabetes groups than in the age-matched control groups. Differences in refractive index distribution between persons with and without diabetes are too small to have important effects on instruments measuring axial thickness.
Highlights
To compare lens dimensions and refractive index distributions in type 1 diabetes and age-matched control groups
Smaller lens diameters occurred in the diabetes groups than in the age-matched control groups
We considered the effects of type 1 diabetes on accommodation,[2] ocular straylight, and lens yellowing.[3]
Summary
There were 17 participants with type 1 diabetes, consisting of two subgroups (7 young [23 6 4 years] and 10 older [54 6 4 years] participants), with controls (13 young, 6 4 years; 10 older, 55 6 4 years). One eye was tested with relaxed accommodation. The participants were a subgroup of a study on the optics of the eyes of people with type 1 diabetes. The majority were recruited from the Longitudinal Assessment of Neuropathy in Diabetes using novel ophthalmic Markers (LANDMark) study at the Institute of Health and Biomedical Innovation.[13] As mentioned above, all participants with diabetes recruited through LANDMark had low levels of the classic triad of diabetic complications
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