Abstract
Purpose:To evaluate changes in crystalline lens densitometry following corneal cross-linking (CXL) in keratoconic patients.Methods:In a quasi-experimental study, three-dimensional lens densitometry was performed using the Pentacam Scheimpflug camera (Oculus Optikgerate GmbH, Wetzlar, Germany) at baseline and six months after CXL. Densitometry was performed in a fixed area of 2 inch × 1 inch of the anterior capsule and anterior lens cortex. The subject group included patients with progressive keratoconus who underwent CXL (n = 40) and the control group was comprised of aged-matched patients with non-progressive keratoconus (n = 36).Results:Mean age of the case and control groups was 25.8 ± 4.0 and 25.0 ± 4.1 years, respectively (P = 0.392). Mean lens density in the CXL group was 6.68% ± 0.58% at baseline and 6.77% ± 0.53% at the last visit (P = 0.352). Corresponding figures in the control group were 6.53% ± 0.27% and 6.39% ± 0.31%, respectively (P = 0.213). There was no significant difference between the study groups at baseline or six months later (P = 0.96).Conclusion:In this short term study with six months’ follow-up, we observed no significant impact on lens density following exposure of the crystalline lens to ultraviolet A and riboflavin free radicals in the CXL procedure.
Highlights
There was no statistically significant difference in terms of lens density assessed by Pentacam between the study groups at baseline or six month later (P = 0.96)
Collagen cross‐linking is a therapeutic modality for progressive keratoconus and post‐laser in situ keratomileusis (LASIK) ectasia
During CXL, riboflavin in conjunction with Ultraviolet A (UVA) is excited to the triplet state, inducing reactive oxygen species which by diffusion through the cornea, may enter the anterior chamber and come in contact with the crystalline lens
Summary
Following riboflavin exposure to UVA, these molecules.
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