Abstract
Hamartoma, a tumor-like malformation, presents as a mass of disorganized tissue. Leiomyomatous hamartomas (LM) are extremely rare in the oral cavity. This report describes a case of oral LM. An 8-year-old girl was referred for diagnosis of a nodule on the tongue, of unknown duration. An intraoral examination revealed a painless nodule located on the middle-dorsum of the tongue, measuring about 1.0 cm. The main hypothesis of diagnosis was granular cell tumor. The lesion was excised under local anesthesia. Microscopically, the lesion consisted of randomly orientated bundles of spindle-shaped cells located subepithelially, non-encapsulated, surrounded by fibrous tissue stroma, and intermixed with blood vessels. The cells were positive for alpha-smooth muscle actin and h-Caldesmon, and negative for S-100 and CD-34. A diagnosis of LM was established. Although LM may develop at any oral site, it mainly occurs on the dorsum of the tongue in patients during the first year of life.
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