Abstract
SummaryBackgroundCardiac complications contribute significantly to morbidity and mortality in children with HIV/AIDS. These rates have been under-reported in sub-Saharan African children.MethodsThis was an observational, cross-sectional Doppler echocardiographic study of ventricular systolic function, performed at a tertiary clinic on children with HIV/AIDS.ResultsLeft ventricular systolic dysfunction was present in 27.0% of the children with HIV infection and 81.2% of those with AIDS. The mean fractional shortening in the AIDS group (31.6 ± 9.5%) was significantly lower than in the HIV-infected group (35.3 ± 10.5%, p = 0.001). A significant correlation was found with CD4+ cell count and age, and these were the best predictors of left ventricular systolic dysfunction in the stepwise multiple regression analysis (r = 0.396, p = 0.038; r = –0.212, p = 0.025, respectively).ConclusionLeft ventricular systolic dysfunction is common in Nigerian children with HIV/AIDS.
Highlights
Cardiac complications contribute significantly to morbidity and mortality in children with Human immune deficiency virus (HIV)/acquired immune deficiency syndrome (AIDS)
Our study evaluated left ventricular systolic function (LVSF) and factors affecting it in children with HIV and AIDS, compared with age- and gender-matched HIV-negative controls, using M-mode, two-dimensional and Doppler echocardiography
The mean respiratory rate (RR), heart rate (HR) and erythrocyte sedimentation rate (ESR) were significantly higher in the HIV and AIDS groups than in the controls (p < 0.001)
Summary
Cardiac complications contribute significantly to morbidity and mortality in children with HIV/AIDS. These rates have been under-reported in sub-Saharan African children. Methods: This was an observational, cross-sectional Doppler echocardiographic study of ventricular systolic function, performed at a tertiary clinic on children with HIV/AIDS. Results: Left ventricular systolic dysfunction was present in 27.0% of the children with HIV infection and 81.2% of those with AIDS. The mean fractional shortening in the AIDS group (31.6 ± 9.5%) was significantly lower than in the HIV-infected group (35.3 ± 10.5%, p = 0.001). Conclusion: Left ventricular systolic dysfunction is common in Nigerian children with HIV/AIDS
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