Abstract
Gliomas are the most common primary intrinsic brain tumours and Ionizing radiation represents the most effective therapy for their treatment. However, despite successful adoption of innovative technologies, radiotherapy resistance and tumor recurrence still occur in a high proportion of patients. Thus there is great interest in understanding the underlying biology and developing new strategies to overcome radioresistance. The expanding investigation of glioma suggests that epigenetic changes play a critical roles in glioma genesis. DNA methylation and histone modification are key marks that regulate gene expression and thus modulate a wide range of cellular processes. The recent studies suggest that epigenetic state of tumor cell may affect сєіі sensitivity to radiation. Epigenetic markers associated with radioresistance hold promise as predictive biomarkers for therapy response and prognosis. On the other hand the obtained results suggest that radiation induces epigenetic reprogramming of cells which may influences the cell fate or alters the response to future exposure. As epigenetic alterations can potentially be reversed by drug treatment, they are interesting candidate targets for radiotherapy sensitizers. This review describes the current knowledge on epigenetics in radiotherapy.
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