LBPS 02-50 HYPERTENSION AND MULTIPLE BRAIN DAMAGE INTEGRITY IN LATE-LIFE DEPRESSION

Abstract

Objective: Aged patients with the long lasting history of hypertension often complain of multiply silent ischemic damage, state that can lead to cognitive retardation, which is due to the injured microvasculature of frontal-subcortical areas, basis,vascular, mood circuit. Hypertension, which causes the lipohyalinosis of small cerebral vessels, may become the main risk-factor for vascular depression. Design and Method: 136 hypertensive patients, aged 68.5 ± 7.5 years, have been investigated. Global cognitive function was evaluated by MMSE. Executive function was researched by neuropsychological test battery (letter fluency, Stroop Test, Wisconsin Card Sorting Test, digit span, letter member sequencing). Hamilton depression scale (HAM-D) was applied. Due to data patients were divided into two groups: I group- 68 patients with treated hypertension and II group,-66 patients with untreated and uncontrolled hypertension. Imaging was performed in MCI patients to exclude another cause of cognitive decline. Two groups were compared in regard of hypertension and its treatment, vascular risk factors, demographic and radiological variables. Results: In a I group depression was established in 11 (16.18%) of hypertensive patients. In 2nd group depression was established in 17 (25.7%) patients. Comparison of these two groups revealed that patients with untreated hypertension have significantly higher incidence of depression, and the more damage from multiple brain lesions, especially in frontal lobe (p > 0.5). Multiple linear logistic regression analysis revealed the significant share of untreated hypertension on development of mild cognitive impairment in late life (p > 0.05). Conclusions: Detection of prehypertension state and treatment of hypertension in early state may prevent the depression and mild cognitive impairment in late life and improve the quality of life in elderly.