LBA02-08 RISK FACTORS FOR INCREASED STENT-ASSOCIATED SYMPTOMS FOLLOWING URETEROSCOPY FOR URINARY STONES: RESULTS FROM THE URINARY STONE DISEASE RESEARCH NETWORK (USDRN) STENTS STUDY

Abstract

You have accessJournal of UrologyCME1 May 2022LBA02-08 RISK FACTORS FOR INCREASED STENT-ASSOCIATED SYMPTOMS FOLLOWING URETEROSCOPY FOR URINARY STONES: RESULTS FROM THE URINARY STONE DISEASE RESEARCH NETWORK (USDRN) STENTS STUDY Jonathan Harper, Hongqiu Yang, Naim Maalouf, Jodi Antonelli, Alana Desai, Henry Lai, Peter Reese, Gregory Tasian, Hunter Wessells, Hussein Al-Khalidi, Ziya Kirkali, and Charles Scales Jonathan HarperJonathan Harper More articles by this author , Hongqiu YangHongqiu Yang More articles by this author , Naim MaaloufNaim Maalouf More articles by this author , Jodi AntonelliJodi Antonelli More articles by this author , Alana DesaiAlana Desai More articles by this author , Henry LaiHenry Lai More articles by this author , Peter ReesePeter Reese More articles by this author , Gregory TasianGregory Tasian More articles by this author , Hunter WessellsHunter Wessells More articles by this author , Hussein Al-KhalidiHussein Al-Khalidi More articles by this author , Ziya KirkaliZiya Kirkali More articles by this author , and Charles ScalesCharles Scales More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002670.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The USDRN STudy to Enhance uNderstanding of sTent-associated Symptoms (STENTS) sought to identify risk factors for increased post-ureteroscopic pain, urinary symptoms, and their interference with daily activities in a prospective multicenter observational cohort study. METHODS: Patients aged ≥12 years undergoing unilateral ureteroscopy with ureteral stent placement for stone treatment were enrolled at 4 U.S. clinical centers. Participants reported symptoms at baseline, on post-operative days (POD) 1, 3, 5, at stent removal, and day 30 post-stent removal using the Brief Pain Inventory short form and PROMIS measures for pain severity and pain interference, the Urinary Score of the Ureteral Stent Symptom Questionnaire, and Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index (LURN SI-10). Multivariable analyses using mixed-effects linear regression models were implemented. RESULTS: 424 participants (396 adults) were enrolled. Median age (years) was 54 in adults and 15 in adolescents; 46.9% were female. Dominant stone location was ureteral in 56% and renal in 44% of participants. Mean ureteroscopy time was 57(SD ±30) min. There was a marked increase in pain and urinary symptoms from baseline to POD 1, with a gradual fall on days 3 to 5, returning below baseline 30 days after stent removal. As pain intensity decreased over time, interference remained elevated. On multivariable regression (Table), older age was associated with less postoperative pain intensity (p=0.004). Having chronic pain conditions (p<0.001), prior severe ureteral stent pain (p=0.021), and depression at baseline (p<0.001) were each associated with higher pain intensity. Neither stone location, ureteral access sheath use, nor stent size were associated with average pain intensity, pain interference, or urinary symptoms. CONCLUSIONS: In this well-characterized, multicenter prospective cohort, interference persisted even as pain intensity decreased over time. Patient factors such as depression, rather than surgical factors, impacted symptom severity. These findings provide a foundation for patient counseling and highlight potential targets for future efforts to mitigate the burden of stent-associated symptoms. Source of Funding: NIH/NIDDK © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e1044 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jonathan Harper More articles by this author Hongqiu Yang More articles by this author Naim Maalouf More articles by this author Jodi Antonelli More articles by this author Alana Desai More articles by this author Henry Lai More articles by this author Peter Reese More articles by this author Gregory Tasian More articles by this author Hunter Wessells More articles by this author Hussein Al-Khalidi More articles by this author Ziya Kirkali More articles by this author Charles Scales More articles by this author Expand All Advertisement PDF DownloadLoading ...