Abstract
The antineoplasic activity of gallic acid has been reported. This compound induces apoptosis and inhibits the growth of several neoplasic cells. However, this molecule is easily oxidized and degraded in the body. The aim of this work was to intercalate gallate ions into layered double hydroxide (LDH) nanoparticles under controlled conditions to reduce oxidation of gallate and to evaluate its toxicity against the A549 adenocarcinoma cell line. An isopropanol medium under nitrogen atmosphere was adequate to intercalate gallate ions with a lesser oxidation degree as detected by electron spin resonance spectroscopy. Concentrations of the hybrid LDH-gallate nanoparticles between 0.39 and 25 µg/mL reduced the cell viability to 67%, while the value reached with the pure gallic acid and LDH was 90% and 78%, respectively, thus proving that the combination of gallate ions with the inorganic nanoparticles increases the toxicity potential within this dose range.
Highlights
Layered double hydroxides (LDHs) are synthetic minerals with positively charged brucite-type layers containing divalent and trivalent cations (M2+ and M3+ )
The inorganic LDH matrix composed by zinc and aluminum was prepared with 2.0026 g of Thereafter, a solution made of 14% ammonia was added until pH 8 was reached
We determined that isopropanol and nitrogen atmosphere are suitable media to prepare the LDH-based nanohybrid with stable gallate ions
Summary
Layered double hydroxides (LDHs) are synthetic minerals with positively charged brucite-type layers containing divalent and trivalent cations (M2+ and M3+ ). A residual electrostatic charge produced by M3+ cations is neutralized by anions (An- ) intercalated between the layers [1]. The proper selection of metal cations allows for the control of biocompatibility; it is possible to design drug carrier systems [1,2,3]. Those nanoparticles loaded with drugs by adsorption or encapsulation improve the sustained release over a long period of time and provide chemical stability to drug molecules.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
