Abstract
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are among the most important severe skin hypersensitivity reactions affecting cutaneous and mucous membranes. The etiology of SJS/TEN is not precisely known, but it's triggered either by drugs most common being anticonvulsants, antibiotics or nonsteroidal antiinflammatory drugs, pregnancy, vaccines or by infections such as Mycoplasma pneumonia, especially in children and adolescents. Present here, a rare case of severe SJS, diagnosed at age of 2 and followed-up till to 17 years, who has long term sequelae of bronchiolitis obliterans, lip adhesion, hematocolpos, finger contractures and ophthalmologic involvement. Conclusion: Multidisciplinary approach is essential in the long term follow up of SJS for the sequelae.
Highlights
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are among the most important severe skin hypersensitivity reactions affecting cutaneous and mucous membranes [1,2]
Based on the involvement of Body Surface Area (BSA), epidermal detachment of more than 30% of BSA is defined as TEN, whereas epidermal detachment of less than10% of BSA is defined as SJS
The involvement of 10%-30% of BSA is named as SJS/TEN overlap
Summary
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are among the most important severe skin hypersensitivity reactions affecting cutaneous and mucous membranes [1,2]. EM are generally triggered by infections and in EM major typical lesions distributed acrally, whereas in SJS trunkal and facial involvement predominates. We hereby report a severe case of SJS survivor who experienced serious long-term sequelae with respiratory, ophthalmologic, genitourinary and cutaneous involvement. Eyelid margin keratinization, symblepharon causing forniceal shortening and severe corneal staining was detected.
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