Abstract
A hospital-based series of 158 patients with neurofibromatosis I, including 138 adults aged >18 years and 20 children, were evaluated for neurological complications in adulthood at the Services de Neurologie and Neuroradiologie, Hopital Henri Mondor, Paris, France.
Highlights
The authors caution that chronic hyperglycemia with inadequate diabetes therapy may have detrimental effects on brain function in children, and the emphasis on dangers of intensive therapy should not neglect the benefits of close control of blood glucose levels
Neurological manifestations observed in 87 (55%) of patients included headache (28 patients), hydrocephalus (7), epilepsy (5), lacunar stroke (1), white matter disease (1), intraspinal neurofibroma (3), facial palsy (1), radiculopathy (5), and polyneuropathy (2)
Pain related to nerve and spinal tumors occurring in 11 adults, and malignant nerve tumors were found predominantly in adults
Summary
These authors advocate careful monitoring of diabetes control in young children, in those receiving intensive therapy and for conventional diabetes control. Mild hypoglycemia (blood glucose level of 60-65 mg/dL) in a young child may induce a transient inattention and cognitive dysfunction ("hypoglycemic absence episode"), interfering with memory and the ability to learn. The authors caution that chronic hyperglycemia with inadequate diabetes therapy may have detrimental effects on brain function in children, and the emphasis on dangers of intensive therapy should not neglect the benefits of close control of blood glucose levels.
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