Abstract
Myocardial fibrosis, as detected by late gadolinium enhancement (LGE) magnetic resonance imaging (MRI), is related to mortality after aortic valve replacement (AVR). This study aimed to determine whether LGEMRI predicts improvement in global longitudinal strain (GLS) after AVR in patients with severe aortic stenosis (AS). Twenty-nine patients with severe AS who were scheduled to undergo AVR were enrolled. Two-dimensional echocardiography and contrast-enhanced MRI were performed before AVR. GLS and LGEcore (g: > 5 SD of normal area), LGEgray (g: 2–5 SD), and LGEcore+gray (g) were measured. One year after AVR, GLS were examined by echocardiography to assess improvement in LV function. Preoperatively, GLS correlated with LGEcore (g) (r2 = 0.14, p < 0.05), LGEgray (g) (r2 = 0.32, p < 0.01) and LGEcore+gray (g) (r2 = 0.36, p < 0.01). LGEcore was significantly lower in patients with improved GLS after AVR (GLS1year ≥ −19.9%) compared to those with no improvement (1.34 g vs. 4.70 g, p < 0.01). LGE predicts improvement in LV systolic function after AVR.
Highlights
Several studies have reported that global longitudinal strain (GLS), an index of LV systolic function assessed by echocardiography, is reduced even in aortic stenosis (AS) patients with preserved LV ejection fraction (EF)[4]
LVEF was well-preserved at 65.7%, while GLS was reduced at −16.5%
We investigated whether preoperative late gadolinium enhancement (LGE) could predict improvement in GLS after aortic valve replacement (AVR) in patients with preserved LVEF and reduced GLS
Summary
Several studies have reported that global longitudinal strain (GLS), an index of LV systolic function assessed by echocardiography, is reduced even in AS patients with preserved LV ejection fraction (EF)[4]. Impaired GLS is known to correlate with AS severity, increased left ventricular mass index (LVMI)[5], and all-cause mortality in patients with AS6. Few studies have examined which preoperative examinations predict improvement in GLS after AVR.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
