Abstract
Coagulation factors, 11-dehydro-TxB 2 (metabolite of TxA 2) and 6-keto-PGF 1α (metabolite of PGI 2) levels in 87 women who were treated for 9 months with oral contraceptives (OC) containing low doses of oestrogens and progestogens (Triquilar R, Trinovum R or Cilest R) were investigated. In plasma, increases in F I, II, VII, VIII-c and 11-dehydro-TxB 2 levels, but no modification of 6-keto-PGF 1α were observed. In urine, FPA concentration rose, but no change occurred in 11-dehydro-TxB 2 and 6-keto-PGF 1α levels. No marked difference between the 3 OC preparations were noted. These data, and particularly the large increase of 11-dehydro-TxB 2 (p < 0.01), suggest that a hypercoagulable state persists in low dosage OC users.
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