Laktat / albümin oranı, kritik hasta çocuklarda mortalite için etkili bir belirleyicidir

Abstract

Introduction: Many predictive biomarkers were developed to evaluate the prognosis and mortality of critically ill children. Serum lactate level is one common biomarker because hyperlactatemia is associated with mortality in these patients. Previous studies have shown that serum albumin level is also a useful biomarker. Several recent articles suggested that the combination of serum lactate and albumin is a more effective predictor of mortality in critically ill patients. This study aimed to determine whether the lactate/albumin (L/A) ratio was a better prognostic factor than serum lactate level alone. Material and Methods: Thus, we retrospectively investigated the relationship between these biomarkers and their relationship with invasive mechanical ventilation, noninvasive mechanical ventilation support, inotropic drug need, acute renal kidney injury, continuous renal replacement therapy, mortality, and hospitalisation period . Results: A total of 379 patients with a mean age of 4.8±5.3 years (range, 1 month to 18 years) were included in this study. The average duration of stay in the paediatric intensive care unit was 7.4± 11.5 days, and the median L/A ratio was 0.46 (range, 0.11–10.0). Our findings indicate that the L/A ratio and serum lactate level were associated with mortality in critically ill children. However, our analysis also suggested that an L/A ratio of >0.5 upon admission is an overall better predictor of mortality. Conclusion: We conclude that the L/A ratio is a useful and effective predictor of mortality in critically ill children.