Abstract
Background: Lactoferrin, known to be present in mammalian milk, affects immune function. In the present study, we aimed to investigate the effect of lactoferrin on skin moisture and melanin levels in ultraviolet (UV) A-exposed mice. Methods and Findings: Male C57BL/6J mice were administered water or lactoferrin (100mg/kg body weight) via oral gavage and exposed to UV-A. Melanin and moisture levels were measured at 5, 10, and 15 weeks using a moisture checker and mobile skin tone (n=10 or 6, 5 and 10 weeks; n=5 or 4, 15 weeks, respectively). UV-A exposure significantly reduced moisture levels after 5 weeks, which continued over the 15-week duration. Melanin levels were increased significantly after 10 weeks. Treatment with lactoferrin for 15 weeks significantly enhanced moisture levels, reduced by UV-A exposure. Melanin levels were significantly decreased after 15 weeks when compared with the UV-A exposure group. Conclusions: Lactoferrin restored moisture and melanin levels in UV-A-exposed mice. The present study demonstrates the effect of lactoferrin following UV-A exposure. Dietary lactoferrin intake could prevent UV-induced reduction in moisture and enhanced melanin levels.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
