Abstract
Objective: To assess the use of lactate as a marker of tissue hypoperfusion and as a prognostic index in critically ill patients. Methods: Prospective, longitudinal, observational study of 75 patients admitted to the pediatric ICU of Hospital de Clinicas of Universidade Federal do Parana, between November 1998 and May 1999. According to the lactate level on admission, patients were divided into group A (lactate > 18 mg/dl) and group B (lactate 18 mg/dl showed clinical signs of hypoperfusion on admission. The normalization or reduction of lactate levels at and after 24 hours of admission was significantly related with higher chances of survival
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