Lack of effects of acute estradiol on mood in postmenopausal women

Abstract

Chronic treatment with estrogen is believed to improve mood in postmenopausal women, and recent preclinical evidence suggests that estradiol may also affect mood and behavior through acute neuronal membrane-mediated effects on the central nervous system. This study was designed to characterize potential mood effects of single doses of transdermal estradiol in healthy postmenopausal women who were not taking hormone replacement therapy (HRT). Twelve women participated in a five-session, within-subjects, double-blind study, in which they received placebo, transdermal estradiol (0.2, 0.4, and 0.8 mg), or d-amphetamine (15 mg, oral) in a randomized order. Amphetamine was included as a positive control. Dependent measures included self-report measures of mood, physiological measures, and plasma hormone levels. Despite dose-dependent increases in plasma estradiol levels, and despite the fact that d-amphetamine produced its prototypic stimulant-like effects in these postmenopausal women, estradiol did not produce effects on mood. The finding that acute administration of exogenous estradiol did not alter mood suggests that more chronic exposure to estradiol is needed to produce mood-enhancing effects.