Abstract
To investigate the association between the gene polymorphisms of angiotensin-converting enzyme (ACE) and digestive system cancer risk. A search was performed in Pubmed, Medline, ISI Web of Science and Chinese Biomedical (CBM) databases, covering all studies until Sep 1st, 2013. Statistical analysis was performed by using Revman5.2 and STATA 12.0. A total of 15 case-control studies comprising 2,390 digestive system cancer patients and 9,706 controls were identified. No significant association was found between the I/D polymorphism and digestive cancer risk (OR =0.93, 95%CI = (0.75, 1.16), P =0.53 for DD+DI vs. II). In the subgroup analysis by ethnicity and cancer type, no significant associations were found for the comparison of DD+DI vs. II. Results from other comparative genetic models also indicated a lack of associations between this polymorphism and digestive system cancer risks. This meta-analysis suggested that the ACE D/I polymorphism might not contribute to the risk of digestive system cancer.
Highlights
The angiotensin-converting enzyme (ACE) is a major component of the renin-angiotensin system (RAS) and plays a crucial role in the regulation of circulatory homeostasis
ACE is differentially expressed in several malignancies (Bauvois et al, 2004) and influences tumor cell proliferation, tumor cell migration, angiogenesis, and metastatic behavior (Abali et al, 2002; Yoshiji et al, 2002a, b)
Publication search We searched literatures in Pubmed database, Web of Science database, Medline database, Chinese Biomedical database(CBM) to identify articles that evaluated the associations between polymorphisms in ACE gene and digestive system cancer risks (Last search was updated on Sep 1st, 2013).The search terms were used as follows: ‘digestive system neoplasms or digestive cancer or biliary tract neoplasms or liver neoplasms or pancreatic neoplasms or esophageal neoplasms or stomach neoplasms or intestinal neoplasms’ and ‘peptidyl-dipeptidase A or angiotensin-converting enzyme or ACE’ in combination with ‘polymorphism, genetic or polymorphism, single nucleotide or variant or mutation’
Summary
The angiotensin-converting enzyme (ACE) is a major component of the renin-angiotensin system (RAS) and plays a crucial role in the regulation of circulatory homeostasis. Much evidence indicates that ACE associated with the pathology of carcinoma (Abali et al, 2002, Bauvois et al, 2004). ACE is differentially expressed in several malignancies (Bauvois et al, 2004) and influences tumor cell proliferation, tumor cell migration, angiogenesis, and metastatic behavior (Abali et al, 2002; Yoshiji et al, 2002a, b). Epidemiologic studies have indicated that ACE inhibitors might decrease the risk and mortality rate of cancers (Lever et al, 1998). The human ACE gene is located on chromosome 17q23, and many polymorphisms have been identified (Kitsios and Zintzaras, 2009). Insertion (I) or deletion (D) polymorphism of ACE gene has functional relevance, since the carriers of D allele have higher ACE activity (Rigat et al, 1990)
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