Abstract
Purpose Analysis of labyrinthitis in a model of otitis media. Materials and methods Morphologic study in 20 Wistar rats in which otitis media was induced by transbullar inoculation of Pseudomonas aeruginosa with obstruction of the eustachian tube. Results Seventy percent of rats showed vestibular signs. Histologic changes ranged from nonaffected labyrinths to suppurative labyrinthitis. Conclusions Dissemination of infection probably occurs through round window membrane. A thinner round window membrane typical of rodents would be the reason for a more severe clinical and morphologic picture in rats when compared to human beings.
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