Abstract
We report on the successful demonstration of X-ray phase contrast microscopy and micro computed tomography (CT) with a Bragg magnifier microscope (BMM) in a laboratory setup. The Bragg magnifiers, constituted by two channel-cut crystals in asymmetric diffraction, produced a 15X magnification of the X-ray beam, thus enabling high resolution imaging to be attained. The angular sensitivity of the crystals was used to implement analyzer-based phase contrast imaging: acquiring images at different angular positions and the three parametric images (apparent absorption, differential phase and scattering) have been obtained. Micro-CT, with resolution of about 5 μm is demonstrated with the same system. The main limitations, as well as the ways to mitigate them, are discussed with the aid of the experimental data. The technique demonstrated herein extends high-resolution, multi-modal, x-ray imaging and micro-CT to compact laboratory setups, with the potential of broadening the reach of these techniques outside the community of synchrotron users.
Highlights
The recent development of X-ray instrumentation and techniques, in combination with highly efficient X-ray optics and detectors, is enabling laboratory imaging and microscopy experiments, which were so far possible only at the synchrotron sources, on compact setups
Thanks to advances in detection technology and crystal quality, x-ray imaging and microscopy based on x-ray Bragg magnifiers became a reliable alternative to conventional approaches [8]
Recent results demonstrated the impressive capabilities of an Bragg magnifier microscope (BMM) [9,10,11,12,13] for high resolution x-ray microscopy, holography and micro-computed tomography (CT), with synchrotron sources
Summary
The recent development of X-ray instrumentation and techniques, in combination with highly efficient X-ray optics and detectors, is enabling laboratory imaging and microscopy experiments, which were so far possible only at the synchrotron sources, on compact setups. ABI techniques with symmetric crystal diffraction have recently been applied to compact, laboratory x-ray sources [22, 23] This step paves to way to make ABI techniques available to a larger scientific community, enabling multiple contrast sensitivity for applications in medical imaging and the life sciences that traditionally falls outside the synchrotron users community. We here show how to maximize the efficiency of BMM, by coupling a brilliant rotating anode X-ray source with collimating X-ray optics [25] and an efficient detector In this way we can efficiently employ a BMM in a laboratory setup for phase contrast and tomography applications
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