Abstract
Objective Mucinous ovarian carcinomas (MOCs) constitute a rare histotype of primary ovarian carcinomas. Frequent pathogenic molecular alterations include mutations in KRAS, P53 and overexpression of HER2, but without prognostic relevance. As L1-CAM has previously shown prognostic relevance in other epithelial tumors of the female genital tract, we analyzed whether L1-CAM expression affects prognosis of MOC. In addition, we investigated L1-CAM expression in mucinous borderline tumors (MBOT) with and without adjacent MOC to identify its potential role in the pathogenesis of MOC.
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