Abstract
Letters4 October 2005l-Thyroxine plus Liothyronine in HypothyroidismJean Eisinger, MDJean Eisinger, MDFrom Centre Hospitalier de Toulon, F83056 Toulon, France.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-7-200510040-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Although hypothyroid patients have been treated for decades with desiccated thyroid extracts, l-thyroxine is now considered the only therapy. However, several studies have demonstrated differences between the effects of l-thyroxine and liothyronine, and liothyronine has been used in some heart and muscular conditions. Deiodination abnormalities could be induced by casual events, such as selenium deficiency, or by chronic disease.Bunevicius and colleagues (1) demonstrated that hypothyroid patients feel better when they receive combination therapy with l-thyroxine and liothyronine. Escobar-Morreale and colleagues (2) seem to support this patient preference but conclude with arguments that “physiologic combinations of l-thyroxine ...
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