Abstract
Redox signaling is a process by which endogenous oxidants, derived from metabolism, reversibly modify particular thiols on particular proteins to change their functional behavior in an adaptive manner. However, the molecular mechanisms of redox signaling remain largely unknown. In particular, specificity and efficiency of redox signaling remain largely unexplained. The now emerging solution to this conundrum is that redox signaling is mediated and channeled by protein-to-protein redox relay chains. There is growing evidence that H 2 O 2 signals are relayed through thiol peroxidases to neighboring proteins within supramolecular assemblies. Evidence further suggests that so far we may have just glimpsed the ‘tip of the iceberg’, in that redox relay chains are ubiquitous and may also operate for reactive nitrogen and sulfur species.
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