Abstract
A 17-year-old female patient was hospitalized for chronic diarrhea. Since childhood she had experienced recurrent episodes of respiratory tract infections and diarrhea. Endoscopic examination revealed diffuse clustered polypoid nodules in the duodenum. Biopsy specimen showed nodular lymphoid hyperplasia. Common variable immunodeficiency syndrome was suspected and diagnosis was established by demonstrating a significant reduction of plasma gamma-globulin levels. After starting immunoglobulin treatment, daily diarrhea count decreased, and both incidence and severity of respiratory tract infections were significantly reduced. This case report focuses on common variable immunodeficiency syndrome as a potential underlying cause of diarrhea, and the relationship with nodular lymphoid hyperplasia.
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