Korelacija topografske lokalizacije i kliničkih manifestacija u cilju indikacija za hirurško liječenje osteohondroma

Abstract

Introduction. Osteochondroma is the most common type of benign bone tumor which appears in two forms, sessile and pedunculated. It accounts for 50% of all benign tumors of bone tissue with a double tendency towards male population. It is covered by cartilage cap of different thickness. The thickness of the cap over 30 mm can indicate a malign transformation into the secondary chondrosarcoma. Aim of the study. Determine if there is a correlation between epidemic characteristics of the patients, pathohistologic characteristics, thickness of the cartilage cap and biological behavior of the tumor. Patients and methods. Cross-sectional study included 37 patients which were diagnosed with osteochondroma in the period of 12 months, during the year 2014, at the Institute for pathology of Medical Faculty in Belgrade. The patients’ age, sex, localization, clinical manifestation and length of the case history were descriptively determined. The thickness of the cartilage cap was morphometrically determined on pathohistologic devices of re-sectioned tumors. Out of 37 patients with diagnosed osteochondroma, 3 of them (8%) had malign alteration of the cartilage cap. The thickness of the cartilage cap in all the 3 of them was over 30 mm, ranging from 68-120 mm. Relapse was found in 3 patients (8%). Discussion. The highest importance of this lesion comes from the fact that it is the most common bone tumor with high incidence and possibility for malign transformation of the cartilage cap into secondary chondrosarcoma which makes this tumor interesting for medical staff at the clinic and pathologists. Conclusion. The width of a cartilage cap, in correlation with clinical and radiology parameters, is a significant predictive parameter of biological behavior of osteochondroma.