Abstract
BackgroundHypertension and diabetes are among the most important risk factors of cardiovascular diseases. Klotho and SIRT1 are known as anti-aging factors with beneficial effects on cardiovascular system. In this study we investigated the serum Klotho and SIRT1 levels in pre-diabetic and pre-hypertensive individuals and then in diabetic and hypertensive patients to see their relationship with these diseases.Method229 individuals divided into six groups with similar gender and age distribution 1—Control (normal BP and FBS) 2—pre-diabetic (FBS between 100 and 125 mg/dl) 3—diabetic (FBS ≥ 126 mg/dl), 4—pre-hypertensive (SBP 120–139 or DBP 80–89 mm Hg) 5—hypertensive (SBP ≥ 140 or DBP ≥ 90 mm Hg), and 6—patients with combined hypertension/diabetes. Serum levels of Klotho and SIRT1 were measured by ELISA method.ResultsSerum Klotho and STRT1 levels decreased in pre-diabetes and returned to normal in diabetic patients. Their concentration increased in pre-hypertension and recovered to normal in hypertension. In the physiologic range of FBS there is a negative correlation between Klotho and SIRT1 with FBS. When pathologic ranges of FBS added to analysis, the negative correlation abolished/U shaped. Also an inverse U shape correlation observed between Klotho and SIRT1 with MAP in the range of normal to hypertensive BP levels. There was an overall positive relationship between the serum levels of Klotho and SIRT1 themselves.ConclusionThe serum levels of the anti-aging proteins Klotho and SIRT1 increases or reduces at the onset of the disease, as a compensatory mechanism, but as the disease progresses their level recovers.
Highlights
Hypertension is a complex disorder caused by various genetic, environmental, and social factors [1]
An inverse U shape correlation observed between Klotho and SIRT1 with Mean arterial pressure (MAP) in the range of normal to hypertensive blood pressure (BP) levels
Serum Klotho and SIRT1 levels Serum Klotho level was significantly lower in people with pre-Diabetes mellitus (DM) compared to the control and DM groups, while in DM patients the serum level recovered to control level
Summary
Hypertension is a complex disorder caused by various genetic, environmental, and social factors [1]. In the United States, diabetes is the leading cause of end stage renal disease (ESRD), lower limb amputation, and blindness in adults. It is a predisposing factor for cardiovascular disease. As its global prevalence increases, diabetes is likely to be the leading cause of future disability and mortality [4]. It is Yeganeh‐Hajahmadi et al Diabetol Metab Syndr (2021) 13:115 important to study the underlying mechanisms of hypertension and diabetes. Hypertension and diabetes are among the most important risk factors of cardiovascular diseases. In this study we investigated the serum Klotho and SIRT1 levels in pre-diabetic and pre-hypertensive individuals and in diabetic and hypertensive patients to see their relationship with these diseases
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