Abstract
Objective To investigate the expression of KL-6 mucin in pancreatic ducatal tissue,and to explore its clinical significance.Methods All specimens form 38 patients who were diagnosed as pancreatic ductal adenocarcinoma were subjected to immunohistochemical analysis using KL-6 monoclonal antibody.Results 100％ specimens of pancreatic adenocarcinoma were found positive staining,and marked positive staining was 78.9％,remarkable positive staining was not found in the surrounding noncancer regions of the pancreatic tissues (72.3％).KL-6 mucin expression was statistical significance with the tumor development and differentiation.Conclusion Most of all pancreatic adenocarcinoma cases showed remarkable positive staining for KL-6 mucin,while the majority of surrounding non-cancer regions did not.The aberrant expression of KL-6 mucin is significantly related to aggressive tumor behaviors of pancreatic adenocarcinoma.KL-6 mucin may be a specific target to detect the pancreatic adenocarcinoma in molecular imaging study. Key words: Pancreatic ductal adenocarcinoma; KL-6 mucin; Immunohistochemical
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