Abstract
Lymphocytes from the cervical lymph nodes of guinea pigs were incubated in medium No. 199 for 24 h in the presence of cortisol in concentrations of 20 and 100 μg/100 ml. The survival rate of the lymphocytes and their cortisol metabolism were determined and their nucleic acid concentration was estimated cytophotometrically. In intact and sensitized guinea pigs progesterone, in a concentration of 10−5 M, inhibited both the lytic action of cortisol and its metabolism. A marked decrease in cortisol metabolism by the lymphocytes was found from the sixth day after sensitization, and it did not recover until the 90th day. On the 17th-30th day the cortisol-resistant lymphocyte population was increased. In a concentration of 100 μ g/100 ml cortisol reduced the nucleic acid concentration in lymphocytes both of the intact guinea pigs and also of the sensitized animals on the 17th-30th day, when the cortisol-resistant cell population was increased.
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